Table 6

Nefazodone concentrations (μmol/l) in serial dilution tubes determined by HPLC6-a

5 mmol/l HClAssay Buffer6-b
502.4183.8  ± 35.2
317.072.0  ± 6.0
200.033.6  ± 2.6
126.217.5  ± 3.7
79.68.4  ± 0.9
50.23.9  ± 0.3
31.71.7  ± 0.4
20.00.82  ± 0.04

  • ↵6-a Serial dilutions performed in 5 mmol/l HCl were identical with those made in mobile phase. Only a single injection was tested for each concentration for each series of dilutions.n = 5 for each concentration.

  • ↵6-b Assay buffer is that used for [3H]citalopram binding (table 1).