Effect of BMY 7378 pretreatment on the inhibition of developed tension produced by 10 μM CEC
| Tissue | Developed tension | ||||
|---|---|---|---|---|---|
| Control alone | BMY 7378 alone | CEC alone | 30 nM BMY 7378 + CEC | 100 nM BMY 7378 + CEC | |
| g | |||||
| Aorta | 1.18 ± 0.12 | 1.08 ± 0.26 | 0.3 ± 0.02 | 0.73 ± 0.183-a | N.D. |
| Femoral | 0.73 ± 0.12 | 0.99 ± 0.18 | 0.53 ± 0.13 | 0.66 ± 0.053-a | 0.65 ± 0.033-a |
| Iliac | 1.35 ± 0.08 | 1.14 ± 0.1 | 0.69 ± 0.06 | 0.86 ± 0.083-a | 1.11 ± 0.193-a |
| Mesenteric resistance | 1.64 ± 0.13 | 1.59 ± 0.2 | 1.26 ± 0.12 | 1.21 ± 0.07 | 1.18 ± 0.05 |
| Superior Mesenteric | 0.85 ± 0.19 | 0.93 ± 0.17 | 0.55 ± 0.08 | 0.7 ± 0.073-a | 1.2 ± 0.093-a |
↵3-a Statistically greater response than CEC alone.
N.D., not determined.