Table 1

Activation, inactivation, equilibrium binding and upregulation of human AChRs by nicotine

AChR typeActivationNicotine
AChNicotineInactivationEquilibrium bindingUp-regulation
EC50(tnH)IC50KDEC50
μM
α4β21.9  ± 0.31  (1.1)0.30  ± 0.04  (1.5)0.017  ± 0.00310.00401-b 0.211-b
α779.0  ± 0.51-a  (2.3)40.0  ± 1.61-a  (2.0)0.0028  ± 0.000411.31-a 65.01-c
α3β2β4α56.8  ± 0.5  (0.8)3.0  ± 0.31  (1.0)0.87  ± 0.330.0201-c 100.01-c
  • 1-a From Ref. Peng et al. (1993).

  • 1-b From Ref. Peng et al. (1994) (chicken α4β2).

  • 1-c From Ref. Peng et al. (1997).