Comparison of the antinociceptive effects of dexmedetomidine and ST-91
| Harlan Sprague-Dawley | |||
| Tail-flick | Dexmedetomidine | > | ST-91 |
| 3.4 | (partial agonist) | ||
| (1.9–5.3) | |||
| Hot-plate | Dexmedetomidine | < | ST-91 |
| (partial agonist) | 15.5 | ||
| (8.2–35.3) | |||
| Sasco Sprague-Dawley | |||
| Tail-flick | Dexmedetomidine | > | ST-91 |
| 4.3 | (partial agonist) | ||
| (2.9–6.0) | |||
| Hot-plate | Dexmedetomidine | < | ST-91 |
| (inactive) | (partial agonist) |
Given are relative efficacies of dexmedetomidine and ST-91 in each test of nociception in each substrain. ED50 (95% CL) values (in nmol) are listed for full agonists.