Table 2

Comparison of the antinociceptive effects of dexmedetomidine and ST-91

Harlan Sprague-Dawley
 Tail-flickDexmedetomidine>ST-91
3.4(partial agonist)
(1.9–5.3)
 Hot-plateDexmedetomidine<ST-91
(partial agonist)15.5
 (8.2–35.3)
Sasco Sprague-Dawley
 Tail-flickDexmedetomidine>ST-91
4.3(partial agonist)
(2.9–6.0)
 Hot-plateDexmedetomidine<ST-91
(inactive)(partial agonist)

Given are relative efficacies of dexmedetomidine and ST-91 in each test of nociception in each substrain. ED50 (95% CL) values (in nmol) are listed for full agonists.