Table 1

Summary of the antinociceptive effects of dexmedetomidine and ST-91: Comparison between Harlan and Sasco rats

Dexmedetomidine
 Tail-flickHarlan=Sasco
 3.44.3
(1.9–5.3)(2.9–6.0)
 Hot-plateHarlan>Sasco
(partial agonist)(inactive)
ST-91
 Tail-flickHarlan=Sasco
(partial agonist)(partial agonist)
 Hot-plateHarlan>Sasco
15.5(partial agonist)
 (8.2–35.3)

Given are relative efficacies of dexmedetomidine and ST-91 in each substrain as a function of the test of nociception. ED50 (95% CL) values (in nmol) are listed for full agonists.