Summary of the antinociceptive effects of dexmedetomidine and ST-91: Comparison between Harlan and Sasco rats
| Dexmedetomidine | |||
| Tail-flick | Harlan | = | Sasco |
| 3.4 | 4.3 | ||
| (1.9–5.3) | (2.9–6.0) | ||
| Hot-plate | Harlan | > | Sasco |
| (partial agonist) | (inactive) | ||
| ST-91 | |||
| Tail-flick | Harlan | = | Sasco |
| (partial agonist) | (partial agonist) | ||
| Hot-plate | Harlan | > | Sasco |
| 15.5 | (partial agonist) | ||
| (8.2–35.3) |
Given are relative efficacies of dexmedetomidine and ST-91 in each substrain as a function of the test of nociception. ED50 (95% CL) values (in nmol) are listed for full agonists.