Table 4

Comparison of models for fitting of Eadie-Hofstee plots in dogs

ModelKm1 (μM)Vmax1 (nmol/min/g Liver)Km2 (μM)Vmax2 (nmol/min/g Liver)CLns (ml/min/g Liver)AIC
1-Saturable +1-nonsaturable19.8  ± 5.928.7  ± 7.61.00  ± 0.05−27.6
2-Saturable8.4  ± 3.711.4  ± 4.52928  ± 8473700  ± 795−31.7
2-Saturable +1-nonsaturable8.1  ± 3.210.9  ± 4.1890  ± 249570  ± 1130.65  ± 0.45−35.5
  • The parameters are expressed as means ± S.D. of three experiments.