Table 3
Comparison of kinetic parameters among rats, dogs and humans
| Km1 (μM) | Vmax1 (nmol/min/g liver) | 
(ml/min/g liver) | 
(ml/min/g liver) | Km2 (μM) | Vmax2 (nmol/min/g liver) | 
(ml/min/g liver) |  | CLns (ml/min/g liver) | CLns/CLint, in vitro | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Rat (n = 3) | 13.4 (5.1) | 520 (142) | 38.8 (6.4) | 38.8 (6.4) | 1.00 | ||||||
| Dog (n = 3) | 8.10 (3.2) | 10.9 (4.1) | 1.35 (0.23) | 2.64 (0.64) | 0.511 (0.040) | 890 (249) | 570 (113) | 0.640 (0.057) | 0.242 (0.040) | 0.650 (0.450) | 0.246 (0.119) |
| Human4-a(n = 12) | 1.67 (0.82) | 1.17 (0.72) | 0.759 (0.413) | 0.944 (0.522) | 0.804 (0.080) | 654 (339) | 73.7 (53.2) | 0.123 (0.089) | 0.130 (0.053) | 0.062 (0.064) | 0.066 (0.048) |
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Numbers in parentheses represent the standard deviations of the mean values.
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↵4-a The human data were taken from Iwatsuboet al., 1997b.