Accuracy of human clearance and volume of distribution prediction methods
| Method | n | Average-fold error (xpredicted/xactual) |
|---|---|---|
| V1 | 16 | 1.56 |
| V2 | 16 | 1.56 |
| V3a | 14 | 2.78 |
| V3b | 12 | 1.83 |
| C1a | 7 | 1.95 |
| C1b | 7 | 9.28 |
| C1c | 7 | 1.81 |
| C1d | 7 | 9.39 |
| C2a | 8 | 1.63 |
| C2b | 8 | 8.12 |
| C2c | 8 | 1.67 |
| C2d | 8 | 7.81 |
| C3a | 12 | 3.36 |
| C3b | 14 | 1.91 |
| C3c | 12 | 1.79 |
| C3d | 14 | 2.67 |
A value of unity would indicate that the prediction method was 100% accurate for all predictions made; a value of 2 would indicate that the method is, on average, 2-fold in error. The n values refer to the number of predicted values that were compared with in vivo pharmacokinetic data obtained after intravenous administration.