Compound No. | Molecular weight | Acid, base or neutral | Lipophilicity | CL | VDss | t1/2 | F | Plasma fu | Urinary excretion |
---|---|---|---|---|---|---|---|---|---|
clogP | ml/min/kg | liter/kg | hr | % | % | ||||
1 | 454 | Base | 6.99 | 16 | 0.01 | ||||
2 | 241 | Base | 2.91 | 0.9 | |||||
3 | 222 | Base | 1.48 | 4.0 | 0.7 | 3.5 | 20 | 0.12 | <2 |
4 | 311 | Base | 3.90 | 3.8 | 0.03 | ||||
5 | 412 | Base | 4.42 | 12 | 2.3 | 2.8 | 59 | 0.001 | <1 |
6 | 296 | Base | 3.46 | 15 | 6.6 | 4.7 | 1.0 | 0.19 | <1 |
7 | 404 | Acid | 0.91 | 1.9 | 0.51 | 60 | |||
8 | 380 | Base | 4.10 | 7.4 | 0.07 | ||||
9 | 321 | Neutral | 5.10 | 1.2 | |||||
10 | 387 | Base | 5.97 | 30 | <1 | ||||
11 | 339 | Acid | 4.80 | 1.3 | 0.09 | ||||
12 | 262 | Neutral | 0.62 | 40 | 0.55 | ||||
13 | 291 | Acid | 2.67 | 5.5 | 0.02 | ||||
14 | 369 | Acid | 1.56 | 2.3 | 0.01 | ||||
15 | 620 | Neutral | 4.31 | 1.5 | 0.11 | ||||
16 | 740 | Neutral | 1.83 | 45 | |||||
17 | 329 | Base | 0.19 | 21 | 1.5 | 1.1 | 4.6 | 0.60 | <1 |
18 | 327 | Base | 1.81 | 16 | 5.5 | 4.3 | 0.60 | ||
19 | 375 | Base | 4.37 | 41 | 0.08 | ||||
20 | 414 | Base | 5.50 | 1.0 | 0.07 | ||||
21 | 236 | Neutral | 0.64 | 43 | |||||
22 | 419 | Acid | 2.35 | 27 | 0.006 | ||||
23 | 749 | Base | 1.83 | 68 | 0.93 | 6 | |||
24 | 342 | Base | 5.35 | 26 | 0.02 | <1 | |||
25 | 320 | Acid | 4.69 | 0.1 | 0.1 | 26 | 89 | 0.001 | <2 |
26 | 331 | Acid | 2.70 | 45 | 0.007 | 10 | |||
27 | 338 | Acid | 4.84 | 45 | 0.001 | <1 | |||
28 | 452 | Base | −0.56 | 11 | 70 | 0.28 | 10 | ||
29 | 373 | Acid | 5.59 | 25 | 0.005 | <1 | |||
30 | 428 | Acid | 5.53 | 400 | 0.005 | <1 | |||
31 | 465 | Acid | 4.61 | 30 | 0.01 | <1 | |||
32 | 318 | Neutral | 2.06 | 2.3 | 0.08 | <1 | |||
33 | 299 | Base | 6.09 | 1.0 | 0.004 | <1 | |||
34 | 451 | Base | 3.82 | 1.2 | 1.0 | 11 | 69 | 0.01 | <1 |
35 | 283 | Acid | 2.04 | 7.6 | 0.4 | 0.6 | 70 | 0.16 | 47 |
36 | 408 | Base | 2.78 | 7.0 | 21.0 | 35 | 64 | 0.03 | <1 |
37 | 306 | Neutral | −0.11 | 0.3 | 0.7 | 26 | 80 | 0.89 | 72 |
38 | 283 | Acid | 4.02 | 0.9 | |||||
39 | 395 | Base | 4.00 | 8.0 | 15.1 | 27 | 0.02 | <1 | |
40 | 253 | Base | 1.69 | 3.2 | 1.5 | 5.4 | 93 | 0.43 | 20 |
41 | 376 | Base | 1.53 | 5.9 | 9.0 | 2.4 | 0.02 | 59 | |
42 | 441 | Base | 1.58 | 4.3 | 2.8 | 7.6 | 83 | 0.36 | 65 |
43 | 399 | Acid | 0.18 | 2.3 | 3.4 | 1.6 | 0.01 | 61 | |
44 | 474 | Base | 2.28 | 9.8 | 1.5 | 4.0 | 41 | 0.04 | 1 |
45 | 439 | Base | 2.03 | 3.2 | 0.12 | <1 | |||
46 | 418 | Base | 3.08 | 5.9 | 2.1 | 4.1 | 46 | 0.12 | 8 |
47 | 497 | Acid | 7.21 | 16 | 0.001 | <1 | |||
48 | 582 | Base | 5.22 | 2.5 | 0.01 | ||||
49 | 415 | Base | 5.44 | 33 | 0.002 | ||||
50 | 426 | Base | 3.66 | 3.0 | 0.08 | <1 |
↵1-a A blank entry indicates no data available.