Chemical inhibition of nicotine to cotinine metabolism in human liver microsomes
| Chemical inhibition experiments | Concentration | Inhibition of cotinine formation | Range of inhibition of cotinine formation |
|---|---|---|---|
| μM | % | % | |
| Coumarin | 50 | 77 ± 6 (n = 26) | 66 to 90 |
| Coumarin | 150 | 85 ± 11 (n = 31) | 53 to 94 |
| Orphenadrine | 150 | 20 ± 16 (n = 30) | −22 to 57 |
| Coumarin and orphenadrine | 150 each | 92 ± 11 (n = 30) | 45 to 100 |
| Troleandomycin | 150 | 3 ± 11 (n = 30) | −15 to 30 |