Table 3

Bivariate regression analyses for the combined low, medium and high groups of the single-dose IPK studies and multiple-dose IPK studies

A. Single-dose IPK studies
RelationshipRegression CoefficientSignificance
CLR M vs.GFR0.747 ***
CLR M vs. UFR0.441 ***
CLR M vs. %TR water0.283 **
CLR M − fu · GFR vs. GFR0.658 ***
CLR M − fu · GFR vs.UFR0.400 ***
CLR M − fu · GFRvs. %TR water0.238 *
B. Multiple-dose IPK studies
RelationshipRegression CoefficientSignificance
CLR M vs.GFR0.902 ***
CLR M vs. UFR0.362P  = .0901
CLR M vs. %TR water0.371P  = .0811
CLR M − fu · GFR vs.GFR0.807 ***
CLR M − fu · GFR vs. UFR0.353P  = .0984
CLR M − fu · GFR vs. %TR water0.302P  = .1614

Statistical significance is represented as * P < .05, ** P < .01 and *** P < .001.