Table 2

Pharmacokinetic parameters for morphine disposition observed in single-dose IPK studies, for the low, medium and high morphine concentrations

ParameterConcentration of Morphine in PerfusateStatistical Significance
Low (0.2 μM)Medium (2 μM)High (20 μM)
T1/2(min)121  ± 7571  ± 17103  ± 64P  = .491
CLR(0–90) M (ml/min)1.24  ± 0.361.51  ± 0.291.36  ± 0.78P  = .759
CLM (ml/min)1.35  ± 0.641.88  ± 0.471.70  ± 1.21P  = .676
VK M (ml/g kidney)31  ± 325  ± 926  ± 7P  = .408

Data presented as mean ± SD.