Fraction of morphine unbound in IPK perfusate
| A. Morphine concentration covering a 100-fold range representative of the single-dose IPK studies. | ||
|---|---|---|
| Treatment | Morphine Concentration (μM) | fu |
| Low | 0.1 | 0.727 ± 0.068 |
| Medium | 1 | 0.727 ± 0.012 |
| High | 10 | 0.778 ± 0.009 |
| B. Morphine concentration covering a 1000-fold range representative of the multiple-dose IPK studies. | ||
|---|---|---|
| Treatment | Morphine Concentration (μM) | fu |
| Low | 0.2 | 0.722 ± 0.073 |
| Medium | 2 | 0.743 ± 0.020 |
| High | 20 | 0.773 ± 0.004 |
| Extra High | 200 | 0.719 ± 0.025 |
Data presented as mean ± S.D.