Table 1

Fraction of morphine unbound in IPK perfusate

A. Morphine concentration covering a 100-fold range representative of the single-dose IPK studies.
TreatmentMorphine Concentration (μM)fu
 Low0.10.727  ± 0.068
 Medium10.727  ± 0.012
 High100.778  ± 0.009
B. Morphine concentration covering a 1000-fold range representative of the multiple-dose IPK studies.
TreatmentMorphine Concentration (μM)fu
 Low0.20.722  ± 0.073
 Medium20.743  ± 0.020
 High200.773  ± 0.004
 Extra High2000.719  ± 0.025

Data presented as mean ± S.D.