Cytochrome P450 isoenzyme | Substrate/inhibitor | Concentration | Inhibition | |
---|---|---|---|---|
Riluzole biotransformation | N-Hydroxylation | |||
μM | % | |||
CYP1A1/2 | α-Naphthoflavone | 1 | 80 | 72 |
Caffeine | 400 | 13 | 11 | |
Caffeine | 1000 | 37 | 25 | |
Acetanilide | 1000 | 21 | 18 | |
CYP3A4 | Ketoconazole | 1 | 2 | 1 |
Troleandomycin | 300 | 12 | 17 | |
CYP2D6 | Quinidine | 5 | 20 | 14 |
Quinine (control) | 5 | 19 | 13 | |
CYP2E1 | Chlorzoxazone | 100 | 36 | 28 |
p-Nitrophenol | 100 | 17 | 15 | |
Aniline | 50 | 2 | 8 | |
CYP2C8/9 | Tolbutamide | 50 | 5 | 1 |
CYP2C19 | Omeprazole | 100 | 31 | 24 |