Table 2

Correlation values (r2) of human liver microsomal RP 73401 hydroxylase activity with specific P450 enzyme activities

Enzyme ActivityP450RP 73401 Hydroxylation
Phenacetin O-deethylase (n = 15)1A20.11
Coumarin 7-hydroxylase (n = 15)2A60.85*
7-EFC O-dealkylase (n = 15)2B60.82*
S-Mephenytoin N-demethylase (n = 14)2B60.90*
Tolbutamide hydroxylase (n = 14)2C90.01
S-Mephenytoin 4-hydroxylase (n = 11)2C190.06
Bufuralol 1′-hydroxylase (n = 12)2D60.18
Chlorzoxazone 6-hydroxylase (n = 14)2E10.37
Nifedipine oxidase (n= 15)3A40.37
  • * P < .01, indicating a significant positive correlation.