Correlation values (r2) of human liver microsomal RP 73401 hydroxylase activity with specific P450 enzyme activities
| Enzyme Activity | P450 | RP 73401 Hydroxylation |
|---|---|---|
| Phenacetin O-deethylase (n = 15) | 1A2 | 0.11 |
| Coumarin 7-hydroxylase (n = 15) | 2A6 | 0.85* |
| 7-EFC O-dealkylase (n = 15) | 2B6 | 0.82* |
| S-Mephenytoin N-demethylase (n = 14) | 2B6 | 0.90* |
| Tolbutamide hydroxylase (n = 14) | 2C9 | 0.01 |
| S-Mephenytoin 4-hydroxylase (n = 11) | 2C19 | 0.06 |
| Bufuralol 1′-hydroxylase (n = 12) | 2D6 | 0.18 |
| Chlorzoxazone 6-hydroxylase (n = 14) | 2E1 | 0.37 |
| Nifedipine oxidase (n= 15) | 3A4 | 0.37 |
* P < .01, indicating a significant positive correlation.