Table 1

Kinetic parameters for the metabolism of RP 73401 to RPR 113406 by human liver microsomes and expressed CYP2B6

Microsome SampleKmVmax
μm nmol/min/mg protein
RPR-HL-098.31.01
RPR-HL-1010.20.83
RPR-HL-1226.25.99
CYP2B622.52.35

Incubations and analyses were performed as described under “Materials and Methods.”