Parameter | Slope | Intercept | r | P | n |
---|---|---|---|---|---|
Physicochemical data | |||||
Log RT164-b | 0.281 | 1.34 | .607 | <.025 | 12 |
Log RT194-b | 0.261 | 0.940 | .699 | <.0025 | 15 |
Protein binding (fb) | 0.177 | 0.645 | .868 | <.0005 | 15 |
Log (fu/fb)4-c | −0.340 | −0.275 | .870 | <.0005 | 15 |
Isolated perfused rat liver | |||||
E | 0.172 | 0.587 | .656 | <.005 | 15 |
E4-d | 0.185 | 0.555 | .847 | <.0005 | 14 |
CLapp | 20.4 | 72.9 | .624 | <.01 | 15 |
CLapp 4-d | 22.0 | 68.8 | .819 | <.0005 | 14 |
CLint | 29.1 | 214 | .007 | N.S. | 15 |
CLint 4-d | 43.8 | 112 | .737 | <.0025 | 14 |
CL20 4-e | −0.047 | 0.190 | .306 | N.S. | 14 |
↵4-a calculated by linear correlation analysis (n = number of compounds). Data from tables 1, 2, 3, without data for pipecuronium.
↵4-b logarithm of retention time (min) in HPLC system (16% or 19% dioxane, respectively).
↵4-c logarithm of the ratio of the fraction unbound and the fraction bound to plasma protein.
↵4-d Without data for rocuronium.
↵4-e Without data for Org 9273.