Anticonvulsant potency of neurosteroids and PB alone (vehicle-treated group) and in combination with DZP (0.1 mg/kg) against PTZ-induced seizures
| Treatment | ED50 (Drug + Vehicle) | ED50(Drug + DZP) | ED50 (Drug + Vehicle) | |
|---|---|---|---|---|
| ED50 (Drug + DZP) | ||||
| 3α,5α-P | 2.27 (1.42–3.66) | 1.37 (0.41–4.56) | 1.7 | |
| 3α,5β-P | 2.87 (1.61–5.09) | 0.69 (0.29–1.65)4-a | 4.2 | |
| Ganaxolone | 3.45 (2.34–5.06) | 0.97 (0.37–2.52)4-a | 3.6 | |
| Co 2-1068 | 6.17 (3.47–11.0) | 1.10 (0.37–3.23)4-a | 5.6 | |
| PB | 6.04 (3.26–11.2) | 0.73 (0.34–1.56)4-a | 8.3 | |
The table shows the ED50 values (in mg/kg with 95% confidence limits in parentheses) of the drugs alone (drug + vehicle) (control groups reprinted from table 1 for comparison) and in combination with DZP (0.1 mg/kg). The ratio of ED50 (drug + vehicle)/ED50 (drug + DZP) was also calculated.
↵4-a P < .05; compared to appropriate control ED50 value (Litchfield and Wilcoxon, 1949).