Human postmortem brain tissue parameters and [3H]nicotine binding data
Sample Number | Mental Illness | Smoker | Packs/day | Pack Years | Age | COD | PMI | Storage | Hippocampus Binding | Thalamus Binding |
---|---|---|---|---|---|---|---|---|---|---|
yr | hr | days | fmol/mg protein | |||||||
Nonsmokers | ||||||||||
SB154a,b | No mental illness | no | 65 | adis | 11 | 888 | 5.5 | na | ||
SL164 | No mental illness | no | 69.9 | card | 5.5 | 103 | 6.8 | 22.4 | ||
SL128 | No mental illness | no | 80.3 | cdis | 22.5 | 763 | 7.4 | 30.9 | ||
SL136 | No mental illness | no | 26.5 | card | 15.5 | 646 | 9.8 | 45.9 | ||
SL096 | Clinical depression | no | 50.5 | card | 24 | 1281 | 9.9 | 41.8 | ||
SL166 | No mental illness | no | 39.3 | cdis | 24 | 91 | 10.0 | 24.2 | ||
SL107 | No mental illness | no | 59.9 | suic | 19 | 1147 | 11.1 | 54.9 | ||
SL111 | No mental illness | no | 76.7 | card | 14 | 1049 | 12.1 | 37.8 | ||
SL130 | No mental illness | no | 19.7 | suic | 14 | 756 | 14.1 | 53.4 | ||
SL153 | No mental illness | no | 41.7 | card | 8 | 328 | 16.4 | 24.5 | ||
SL139 | No mental illness | no | 37.6 | adis | 5 | 643 | 18.9 | 30.5 | ||
Means | 0 | 0 | 51.5 ± 6.1 | 14.7 ± 2.1 | 700 ± 120 | 11.08 ± 1.23 | 36.63 ± 3.81 | |||
Smokers | ||||||||||
SL0191-a | No mental illness | yes | 0.5 | 28 | 71 | cdis | 9 | 1336 | 7.5 | na |
SL116 | No mental illness | yes | 0.5 | 60 | 68 | cdis | 5.5 | 993 | 8.4 | 32.4 |
SL147 | No mental illness | yes | 1 | 27 | 75.1 | cdis | 6.5 | 404 | 8.4 | 42.7 |
SL146 | No mental illness | yes | 2.5 | 120 | 62.9 | card | 14 | 413 | 16.2 | 40.9 |
SB151a,b | No mental illness | yes | 1 | 50 | 59 | cdis | 24 | 899 | 16.3 | na |
SL085 | No mental illness | yes | 1 | 34 | 49.7 | card | 7 | 1338 | 17.0 | 58.5 |
SL112 | Anxiety disorder | yes | 2.25 | 120 | 72.7 | card | 11 | 1045 | 17.8 | 46.2 |
SL129 | Alcoholic | yes | 1 | 5 | 32.3 | suic | 14.5 | 756 | 18.6 | 47.7 |
SL0061-a | No mental illness | yes | 2 | 82 | 61 | card | 20 | 1664 | 19.5 | na |
SL142 | Alcoholic | yes | 2.5 | 125 | 59.9 | suic | 17.5 | 510 | 22.9 | 48.3 |
SL148 | Depression | yes | 1 | 35 | 49.6 | suic | 16.5 | 384 | 25.9 | 59.3 |
SL0101-a | No mental illness | yes | 1.5 | 38 | 41 | card | 7 | 1418 | 26.8 | na |
SL062 | No mental illness | yes | 1.5 | 45 | 57.4 | trma | 15 | 1407 | 26.9 | 36.2 |
SL087 | Alcoholism | yes | 3.5 | 95 | 43.3 | card | 22 | 1323 | 27.4 | 44.7 |
SL132 | No mental illness | yes | 1.5 | 63 | 50.5 | card | 6 | 741 | 27.9 | 71.9 |
SL084 | Alcoholic | yes | 1.5 | 50 | 43.9 | card | 20 | 1373 | 29.3 | 87.1 |
SL158 | No mental illness | yes | 2.2 | 110 | 67.3 | card | 5.5 | 259 | 30.6 | 71.2 |
SL123 | No mental illness | yes | 2 | 28 | 52.1 | adis | 5.5 | 804 | 30.8 | 65.6 |
SL126 | Clinical depression | yes | 1.5 | 55 | 52.8 | card | 4.5 | 790 | 32.3 | 83.4 |
SL098 | Alcoholic | yes | 1.5 | 12 | 26 | suic | 14 | 1266 | 37.1 | 70.9 |
SL0071-a | Alcoholic-quit | yes | 2 | 70 | 79 | adis | 16 | 1476 | 46.0 | na |
Means | 1.6 ± 0.16 | 59.6 ± 7.9 | 55.9 ± 3.1 | 12.4 ± 1.4 | 980 ± 93 | 23.5 ± 2.13 | 56.68 ± 4.2 | |||
Smokers who had quit | ||||||||||
SL0211-a | No mental illness | yes, quit 1 yr | 0.33 | 20 | 71 | cdis | 19 | 1049 | 4.2 | na |
SL168 | No mental illness | yes, quit 30 yr | 0.25 | 10 | 75.8 | adis | 19.5 | 15 | 3.4 | 20.0 |
SL167 | No mental illness | yes, quit 10 yr | 1 | 42 | 66 | adis | 22.5 | 42 | 6.3 | 24.9 |
SL160 | Alcoholic | yes, quit 5 yr | 1.5 | 40 | 57.1 | card | 18 | 236 | 6.8 | 29.6 |
SL0161-a | Alcoholic | yes, quit unk | 0.75 | 40 | 70 | cdis | 33 | 1372 | 6.8 | na |
SL0081-a | No mental illness | yes, quit 2 mo | 1.5 | 75 | 66 | card | 12 | 1476 | 10.0 | na |
SL140 | No mental illness | yes, quit 3 yr | 0.75 | 25 | 45 | card | 5 | 629 | 11.0 | 55.9 |
SL133 | No mental illness | yes, quit 25 yr | 0.75 | 10 | 51.7 | card | 17.5 | 734 | 13.6 | 53.8 |
L055 | Clinical depression | yes, quit 3 yr | 1 | 20 | 44.2 | adis | 7 | 1433 | 14.8 | 21.3 |
Means | 0.87 ± 0.15 | 31.3 ± 6.9 | 60.8 ± 3.9 | 17.0 ± 2.8 | 776 ± 196 | 8.54 ± 1.34 | 34.26 ± 6.65 |
Abbreviations: COD, cause of death; PMI, postmortem interval; COD codes: adis: acute disease; cdis: chronic disease; card: cardiac disease; suic: suicide; trma: trauma; na, not analyzed.
↵1-a Denotes samples used for Scatchard analysis.
1-b Denotes tissue from another brain bank located at the UCHSC campus.