Table 1

Human postmortem brain tissue parameters and [³H]nicotine binding data

Sample Number	Mental Illness	Smoker	Packs/day	Pack Years	Age	COD	PMI	Storage	Hippocampus Binding	Thalamus Binding
					yr		hr	days	fmol/mg protein
Nonsmokers
SB154^a,b	No mental illness	no			65	adis	11	888	5.5	na
SL164	No mental illness	no			69.9	card	5.5	103	6.8	22.4
SL128	No mental illness	no			80.3	cdis	22.5	763	7.4	30.9
SL136	No mental illness	no			26.5	card	15.5	646	9.8	45.9
SL096	Clinical depression	no			50.5	card	24	1281	9.9	41.8
SL166	No mental illness	no			39.3	cdis	24	91	10.0	24.2
SL107	No mental illness	no			59.9	suic	19	1147	11.1	54.9
SL111	No mental illness	no			76.7	card	14	1049	12.1	37.8
SL130	No mental illness	no			19.7	suic	14	756	14.1	53.4
SL153	No mental illness	no			41.7	card	8	328	16.4	24.5
SL139	No mental illness	no			37.6	adis	5	643	18.9	30.5
Means			0	0	51.5 ± 6.1		14.7 ± 2.1	700 ± 120	11.08 ± 1.23	36.63 ± 3.81
Smokers
SL019^1-a	No mental illness	yes	0.5	28	71	cdis	9	1336	7.5	na
SL116	No mental illness	yes	0.5	60	68	cdis	5.5	993	8.4	32.4
SL147	No mental illness	yes	1	27	75.1	cdis	6.5	404	8.4	42.7
SL146	No mental illness	yes	2.5	120	62.9	card	14	413	16.2	40.9
SB151^a,b	No mental illness	yes	1	50	59	cdis	24	899	16.3	na
SL085	No mental illness	yes	1	34	49.7	card	7	1338	17.0	58.5
SL112	Anxiety disorder	yes	2.25	120	72.7	card	11	1045	17.8	46.2
SL129	Alcoholic	yes	1	5	32.3	suic	14.5	756	18.6	47.7
SL006^1-a	No mental illness	yes	2	82	61	card	20	1664	19.5	na
SL142	Alcoholic	yes	2.5	125	59.9	suic	17.5	510	22.9	48.3
SL148	Depression	yes	1	35	49.6	suic	16.5	384	25.9	59.3
SL010^1-a	No mental illness	yes	1.5	38	41	card	7	1418	26.8	na
SL062	No mental illness	yes	1.5	45	57.4	trma	15	1407	26.9	36.2
SL087	Alcoholism	yes	3.5	95	43.3	card	22	1323	27.4	44.7
SL132	No mental illness	yes	1.5	63	50.5	card	6	741	27.9	71.9
SL084	Alcoholic	yes	1.5	50	43.9	card	20	1373	29.3	87.1
SL158	No mental illness	yes	2.2	110	67.3	card	5.5	259	30.6	71.2
SL123	No mental illness	yes	2	28	52.1	adis	5.5	804	30.8	65.6
SL126	Clinical depression	yes	1.5	55	52.8	card	4.5	790	32.3	83.4
SL098	Alcoholic	yes	1.5	12	26	suic	14	1266	37.1	70.9
SL007^1-a	Alcoholic-quit	yes	2	70	79	adis	16	1476	46.0	na
Means			1.6 ± 0.16	59.6 ± 7.9	55.9 ± 3.1		12.4 ± 1.4	980 ± 93	23.5 ± 2.13	56.68 ± 4.2
Smokers who had quit
SL021^1-a	No mental illness	yes, quit 1 yr	0.33	20	71	cdis	19	1049	4.2	na
SL168	No mental illness	yes, quit 30 yr	0.25	10	75.8	adis	19.5	15	3.4	20.0
SL167	No mental illness	yes, quit 10 yr	1	42	66	adis	22.5	42	6.3	24.9
SL160	Alcoholic	yes, quit 5 yr	1.5	40	57.1	card	18	236	6.8	29.6
SL016^1-a	Alcoholic	yes, quit unk	0.75	40	70	cdis	33	1372	6.8	na
SL008^1-a	No mental illness	yes, quit 2 mo	1.5	75	66	card	12	1476	10.0	na
SL140	No mental illness	yes, quit 3 yr	0.75	25	45	card	5	629	11.0	55.9
SL133	No mental illness	yes, quit 25 yr	0.75	10	51.7	card	17.5	734	13.6	53.8
L055	Clinical depression	yes, quit 3 yr	1	20	44.2	adis	7	1433	14.8	21.3
Means			0.87 ± 0.15	31.3 ± 6.9	60.8 ± 3.9		17.0 ± 2.8	776 ± 196	8.54 ± 1.34	34.26 ± 6.65

Abbreviations: COD, cause of death; PMI, postmortem interval; COD codes: adis: acute disease; cdis: chronic disease; card: cardiac disease; suic: suicide; trma: trauma; na, not analyzed.
↵1-a Denotes samples used for Scatchard analysis.
1-b Denotes tissue from another brain bank located at the UCHSC campus.