Table 1

Human postmortem brain tissue parameters and [3H]nicotine binding data

Sample NumberMental IllnessSmokerPacks/dayPack YearsAgeCODPMIStorageHippocampus BindingThalamus Binding
yrhrdaysfmol/mg protein
Nonsmokers
 SB154a,b No mental illnessno65adis118885.5na
 SL164No mental illnessno69.9card5.51036.822.4
 SL128No mental illnessno80.3cdis22.57637.430.9
 SL136No mental illnessno26.5card15.56469.845.9
 SL096Clinical depressionno50.5card2412819.941.8
 SL166No mental illnessno39.3cdis249110.024.2
 SL107No mental illnessno59.9suic19114711.154.9
 SL111No mental illnessno76.7card14104912.137.8
 SL130No mental illnessno19.7suic1475614.153.4
 SL153No mental illnessno41.7card832816.424.5
 SL139No mental illnessno37.6adis564318.930.5
  Means0051.5 ± 6.114.7 ± 2.1700 ± 12011.08 ± 1.2336.63 ± 3.81
Smokers
 SL0191-a No mental illnessyes0.52871cdis913367.5na
 SL116No mental illnessyes0.56068cdis5.59938.432.4
 SL147No mental illnessyes12775.1cdis6.54048.442.7
 SL146No mental illnessyes2.512062.9card1441316.240.9
 SB151a,b No mental illnessyes15059cdis2489916.3na
 SL085No mental illnessyes13449.7card7133817.058.5
 SL112Anxiety disorderyes2.2512072.7card11104517.846.2
 SL129Alcoholicyes1532.3suic14.575618.647.7
 SL0061-a No mental illnessyes28261card20166419.5na
 SL142Alcoholicyes2.512559.9suic17.551022.948.3
 SL148Depressionyes13549.6suic16.538425.959.3
 SL0101-a No mental illnessyes1.53841card7141826.8na
 SL062No mental illnessyes1.54557.4trma15140726.936.2
 SL087Alcoholismyes3.59543.3card22132327.444.7
 SL132No mental illnessyes1.56350.5card674127.971.9
 SL084Alcoholicyes1.55043.9card20137329.387.1
 SL158No mental illnessyes2.211067.3card5.525930.671.2
 SL123No mental illnessyes22852.1adis5.580430.865.6
 SL126Clinical depressionyes1.55552.8card4.579032.383.4
 SL098Alcoholicyes1.51226suic14126637.170.9
 SL0071-a Alcoholic-quityes27079adis16147646.0na
  Means1.6  ± 0.1659.6 ± 7.955.9 ± 3.112.4 ± 1.4980 ± 9323.5 ± 2.1356.68 ± 4.2
Smokers who had quit
 SL0211-a No mental illnessyes, quit 1 yr0.332071cdis1910494.2na
 SL168No mental illnessyes, quit 30 yr0.251075.8adis19.5153.420.0
 SL167No mental illnessyes, quit 10 yr14266adis22.5426.324.9
 SL160Alcoholicyes, quit 5 yr1.54057.1card182366.829.6
 SL0161-a Alcoholicyes, quit unk0.754070cdis3313726.8na
 SL0081-a No mental illnessyes, quit 2 mo1.57566card12147610.0na
 SL140No mental illnessyes, quit 3 yr0.752545card562911.055.9
 SL133No mental illnessyes, quit 25 yr0.751051.7card17.573413.653.8
 L055Clinical depressionyes, quit 3 yr12044.2adis7143314.821.3
  Means0.87 ± 0.1531.3 ± 6.960.8 ± 3.917.0 ± 2.8776 ± 1968.54 ± 1.3434.26 ± 6.65
  • Abbreviations: COD, cause of death; PMI, postmortem interval; COD codes: adis: acute disease; cdis: chronic disease; card: cardiac disease; suic: suicide; trma: trauma; na, not analyzed.

  • 1-a Denotes samples used for Scatchard analysis.

  • 1-b Denotes tissue from another brain bank located at the UCHSC campus.