Table 1

Interindividual variation in DTZ N-demethylation in human hepatic microsomes

LiverMedicationN-Desmethylated DTZ formation
nmol/mg of protein/min
HL1Ranitidine0.78
HL2Oxazepam, α-methyldopa0.64
HL4None1.40
HL10Dopamine, desmopressin0.94
HL161-a Dopamine, desmopressin1.33
HL17Colloidal bismuth subcitrate, sucralfate0.66
HL22Unknown1.92
HL24Flucloxacillin, ceftriaxone3.31
HL25Enalapril1.93
HL26Dopamine, imipenem1.87
HL271-a Dopamine, desmopressin1.06
HL28Unknown0.62
HL29Simvastatin0.90
HL30Epinephrine, ranitidine, penicillin0.55
HL311-a Dexamethasone, dopamine, desmopressin0.55
HL32Prazosin0.33
HL34Alprazolam, dexamethasone0.95
Median0.92
Range0.33–3.31

  • ↵1-a Cigarette smoker.