Table 2

Effects of TCA, organic anions, organic cations and ouabain on the uptake of GPFX (5 μM) by isolated rat hepatocytes

Anions or Neutal (μM)	% of Control (PS_inf)	Cations (μM)	% of Control (PS_inf)
Control	100.0 ± 4.1	Control	100.0 ± 2.9
TCA 20	91.2 ± 12.9	Cimetidine 30	93.5 ± 2.7
100	91.0 ± 8.2	100	91.8 ± 2.1
500	92.5 ± 7.4	300	85.4 ± 2.0
DBSP 5	96.5 ± 4.2	PAEB 20	97.7 ± 1.8
20	93.3 ± 3.7	200	110.9 ± 10.2
100	99.2 ± 7.0	d-Tubocurarine 20	96.7 ± 2.7
ICG 5	92.1 ± 2.3	200	98.0 ± 4.4
20	77.9 ± 12.2	Quinidine 3	85.7 ± 3.5
100	90.2 ± 18.5	30	79.7 ± 2.9
Pravastatin 20	87.2 ± 12.0	100	63.9 ± 4.7^2-a
100	100.1 ± 7.8	Verapamil 3	93.6 ± 4.8
500	81.3 ± 4.9	30	84.2 ± 5.0
Ouabain 20	90.6 ± 5.6	100	72.9 ± 5.0^2-a
200	89.6 ± 4.4	Vincristine 20	86.6 ± 6.5
500	88.3 ± 4.3	200	77.3 ± 7.7^2-b
		500	56.0 ± 8.0^2-a

Uptake of [¹⁴C]-GPFX was measured with or without TCA, organic anion, cations or TCA. Each bar represents the mean ± S.E. six to nine determinations in two to three different preparations.
↵2-a P < .01.
↵2-b P < .05, (significantly different from controls using Dunnett’s test).