Table 1

Effects of quinolone antibiotics on the uptake of GPFX (5 μM) by isolated rat hepatocytes

Quinolone Concentration (μM)	% of Control (PS_inf)
Quinolone Concentration (μM)	CPFX	LFLX	ENX	OFLX	SPFX	GPFX
100	87.0 ± 2.9^1-a	85.2 ± 4.4^1-a	90.0 ± 5.3	78.9 ± 5.2^1-a	87.7 ± 7.7	68.3 ± 3.4^1-b
300	82.5 ± 6.0^1-a	77.9 ± 8.2^1-a	75.1 ± 3.7^1-b	71.7 ± 5.0^1-b	71.9 ± 4.4^1-b	56.1 ± 2.5^1-b
1000	n.d.^1-c	64.6 ± 4.1^1-b	n.d.^1-c	59.1 ± 4.5^1-b	59.0 ± 2.5^1-b	42.7 ± 3.9^1-b

Each plot represents the mean ± S.E. of 6 to 15 determinations in 2 to 5 different preparations.
↵1-a P < .05.
↵1-b P < .01 (significantly different from controls using Dunnett’s test).
↵1-c n.d., Not determined due to solubility limitations.