Relative lack of modification of locomotor activity by S 15535 in comparison with dopaminergic agents in rats and mice3-a
| Drug | Route | Dose | Ambulation Counts (rats) | n | Ambulation Counts (mice) | n |
|---|---|---|---|---|---|---|
| Vehicle | s.c. | – | 62.3 ± 5.6 | 16 | 302.5 ± 17.4 | 15 |
| S 15535 | s.c. | 2.5 | 46.1 ± 7.3 | 7 | 320.7 ± 30.4 | 6 |
| 10.0 | 46.8 ± 7.6 | 9 | 211.6 ± 30.7 | 7 | ||
| 40.0 | 29.5 ± 5.8* | 8 | 146.4 ± 20.3* | 8 | ||
| Amphetamine | s.c. | 0.16 | 43.8 ± 14.6 | 8 | – | |
| 0.63 | 146.8 ± 24.2* | 12 | 202.3 ± 48.5 | 7 | ||
| 2.5 | 238.6 ± 22.0* | 12 | 586.6 ± 60.5* | 5 | ||
| 10.0 | – | 569.2 ± 88.4* | 5 | |||
| Haloperidol | s.c. | 0.01 | 51.0 ± 10.1 | 5 | – | |
| 0.04 | 14.2 ± 5.2* | 5 | 268.0 ± 24.2 | 9 | ||
| 0.16 | 6.6 ± 1.8* | 7 | 163.1 ± 14.2* | 9 | ||
| 0.63 | – | 91.2 ± 12.0* | 13 | |||
| 2.5 | – | 27.4 ± 7.2* | 9 | |||
| Buspirone | s.c. | 0.63 | 43.7 ± 9.5 | 7 | 314.0 ± 36.2 | 7 |
| 2.5 | 18.4 ± 11.9* | 7 | 159.6 ± 33.9* | 7 | ||
| 10.0 | 3.0 ± 1.1* | 7 | 126.6 ± 22.4* | 7 | ||
| 40.0 | – | 62.4 ± 10.8* | 7 | |||
| Vehicle | p.o. | – | 31.5 ± 8.0 | 8 | 301.3 ± 34.1 | 7 |
| S 15535 | p.o. | 2.5 | 43.0 ± 5.6 | 6 | 284.5 ± 51.8 | 4 |
| 10.0 | 64.5 ± 9.4 | 6 | 312.7 ± 38.4 | 6 | ||
| 40.0 | 44.1 ± 14.6 | 8 | 284.7 ± 20.2 | 6 |
↵3-a Doses are milligrams per kilogram. Data are means ± S.E.M. Asterisks indicate significance of differences in Dunnett’s test after ANOVA, * ≤ .05.