Antagonist | IC50 | Kb(pKb) |
---|---|---|
nM | ||
Spiperone | 1.48 ± 0.13 | 0.13 ± 0.01 (9.89) |
L 745,870 | 11.7 ± 0.7 | 1.07 ± 0.06 (8.97) |
Haloperidol | 15.0 ± 2.0 | 1.37 ± 0.18 (8.86) |
Clozapine | 533 ± 40 | 48.4 ± 3.7 (7.32) |
Raclopride | >10,000 | >10,000 (<5) |
Antagonist potencies (K b) were calculated from IC50 values for the inhibition of dopamine (1 μM)-stimulated [35S]GTPγS binding. Results are expressed as mean ± S.E.M. of at least three independent experiments.