Table 2

The steady state, clearance, RBR and RCP values together with the percentage losses from the perfusion fluid determined for [3H]AZT and, for comparison, [3H]thymidine2-a, during 2-hr ventriculocisternal perfusion in the rabbit

RCSFClearanceRBRRCPTotal lostLoss to brainLoss to blood
[3H]AZT (n = 3)69.7  ± 2.920.9  ± 3.99.0  ± 1.941.9  ± 16.620.1  ± 4.26.0  ± 1.314.1  ± 3.1
[3H]Thymidine2-a(n = 5–6)46.0  ± 4.144.9  ± 5.511.8  ± 0.8208.3  ± 21.549.2  ± 5.27.6  ± 0.641.6  ± 5.6
P<.01<.05>.05<.01<.01>.05<.05
  • 2-a Data from Thomas et al. (1997).