Effects of mGluR agents on forskolin-induced cAMP formation in rat hippocampal and striatal slices
| cAMP | ||
|---|---|---|
| Hippocampus | Striatum | |
| pmol/mg of protein | ||
| Control | 31 ± 4 | 22 ± 5 |
| Forskolin (30 μM) | 441 ± 981-a | 318 ± 751-a |
| Forskolin (30 μM) | ||
| + (1S,3R)-ACPD (300 μM) | 193 ± 11a,b | 231 ± 44a,b |
| Forskolin (30 μM) | ||
| + AIDA (500 μM) | 380 ± 151-a | 280 ± 601-a |
| Forskolin (30 μM) | ||
| + AIDA (1000 μM) | 200 ± 20a,b | 250 ± 30a,b |
| Forskolin (30 μM) | ||
| + (1S,3R)-ACPD (300 μM) | ||
| + AIDA (500 μM) | 171 ± 23a,b | 232 ± 21a,b |
| Forskolin (30 μM) | ||
| + (1S,3R)-ACPD (300 μM) | ||
| + AIDA (1000 μM) | 190 ± 15a,b | 223 ± 18a,b |
| Forskolin (30 μM) | ||
| + (1S,3R)-ACPD (300 μM) | ||
| + (+)-MCPG (1000 μM) | 425 ± 111-a | 341 ± 501-a |
Values are mean ± S.E.M. of at least 3 experiments conducted in triplicate.
↵1-a P < .01 vs. control.
1-b P < .05 vs. 30 μM forskolin alone.