Table 5

Radioactivity (in rad equivalents) after s.c. infusion of35S-G3139 for 7 days

TimeFreeRadioactivity
PlasmaLiverKidneySpleenHeartLungBone marrowBrainGut
days % μg/ml μg/g μg/g μg/g μg/g μg/g μg/g protein μg/g μg/g
1530.4  ± 0.015.2  ± 228  ± 8.02.1  ± 0.70.25  ± 0.060.4  ± 0.192.4  ± 0.4ND5-a 0.91  ± 0.3
2600.72  ± 0.0213.6  ± 1.888  ± 283.7  ± 1.00.47  ± 0.070.68  ± 0.174.5  ± 0.1ND1.6  ± 0.8
3640.94  ± 0.0220.6  ± 1.574  ± 198.2  ± 3.40.74  ± 0.260.83  ± 0.134.7  ± 0.8ND2.5  ± 0.5
7541.02  ± 0.123.6  ± 7.6102  ± 114.2  ± 0.60.69  ± 0.080.15  ± 0.038.2  ± 0.5ND2.3  ± 0.5
9440.39  ± 0.0614.7  ± 1.841  ± 31.8  ± 0.10.47  ± 0.091.1  ± 0.034.0  ± 1.1ND1.3  ± 0.5
14ND0.15  ± 0.027.0  ± 0.57.5  ± 20.7  ± 0.20.31  ± 0.080.5  ± 0.052.7  ± 0.8ND0.5  ± 0.2
20ND03.1  ± 0.04.0  ± 40.6  ± 0.10.19  ± 0.040.25  ± 0.061.8  ± 0.5ND0.2  ± 0.05
  • 5-a ND, not detectable.