Table 3

Pharmacokinetic parameters, as evaluated with PCNONLIN with compartmental analysis, after 35S-G3139 administration

AUC3-aT1/2αT1/2βT1/2γMRTVssCL
(μg/ml)/hr hr hr hr hr ml/g ml/hr
Plasma i.v.100.080.63114.41337.7
Liver i.v.267123
Kidney i.v.1,82729
Plasma s.c.16022364.7
Liver s.c.4,104110
Kidney s.c.13,80086
  • 3-a AUC, area under the curve; MRT, mean residence time; Vss, steady-state volume of distribution; CL, clearance. AUC values were calculated to the last point by the trapezoidal method.