Table 1

Total radioactivity (in rad equivalents) after i.v. administration of 100 μg of 35S-G3139

TimeFreeRadioactivity
PlasmaLiverKidneySpleenHeartLungBone marrowBrainGut
% μg/ml μg/g μg/g μg/g μg/g μg/g μg/g protein μg/g μg/g
5 min215  ± 1.0
10 min3.39.60  ± 0.9
15 min65.17  ± 0.808.9  ± 0.933  ± 1.410.4  ± 1.95.1  ± 1.15.2  ± 2.52.5  ± 0.10.016.6  ± 1.5
30 min9.62.90  ± 0.609.0  ± 032  ± 4.27.3  ± 1.23.8  ± 0.73.9  ± 0.62.2  ± 0.20.016.6  ± 2.2
1 hr371.20  ± 0.5010  ± 1.539  ± 3.46.5  ± 2.13.6  ± 0.44.4  ± 0.92.1  ± 0.2ND1-a 5.4  ± 1.1
2 hr600.92  ± 0.079.8  ± 0.842  ± 6.55.1  ± 1.63.2  ± 0.63.5  ± 0.51.3  ± 0.3ND2.8  ± 0.5
6 hr720.53  ± 0.0310.6  ± 0.948  ± 5.54.2  ± 1.41.8  ± 0.32.4  ± 0.41.2  ± 0.1ND1.5  ± 0.2
24 hr770.20  ± 0.036.1  ± 0.845  ± 3.22.0  ± 0.10.7  ± 0.10.8  ± 0.21.0  ± 0.4ND0.5  ± 0.1
48 hrND0.11  ± 0.035.1  ± 0.221  ± 3.00.9  ± 0.20.4  ± 0.10.4  ± 0.11.0  ± 0.2ND0.25  ± 0.01
72 hrND0.07  ± 0.033.8  ± 1.213  ± 1.30.8  ± 0.50.2  ± 0.10.3  ± 0.10.8  ± 0.3ND0.17  ± 0.05
  • 1-a ND, not detectable.