Table 4

Effect of probenecid on the amount of [3H]AZT and [3H]DDI remaining in the CSF after icv administration

DrugAmount of Drug Remaining in the CSF4-a
% dose/rat
[3H]AZT2.64  ± 0.35
[3H]AZT + 1.3 mM probenecid4-b 6.40  ± 1.20**
[3H]DDI1.66  ± 0.64
[3H]DDI + 1.3 mM probenecid28.3  ± 3.3**
  • 4-a CSF was collected 30 min after the administration. Each value represents the mean ± S.E. of three rats. ** P < .01.

  • 4-b Concentration of probenecid was expressed as the amount injected per the sum of CSF volume and injection volume,i.e., (0.35 μmol/(250 + 10) μl).