Table 3

Inhibitory effect of AZT, probenecid, deoxyinosine and inosine on the efflux of [3H] DDI from rat brain

InhibitorConcentration in the Brain3-anPercentage Remaining in the Brain3-b
mM
Control3.3  × 10−5DDI672.4  ± 3.9
AZT1.7494.6  ± 3.0**
Probenecid0.33492.6  ± 0.4**
Deoxyinosine1.0483.1  ± 2.1
Inosine1.7384.2  ± 1.6
  • 3-a The brain concentration was estimated from the injectate concentration divided by the dilution factor,i.e., 30.3, which was reported previously (Kakee et al., 1996).

  • 3-b The values were determined 20 min after intracerebral microinjection. Each value represents the mean ± S.E. ** P < .01.