Table 2

Effect of AZT, DDI, thymidine, probenecid, PAH, PCG and DIDS on the efflux of [3H]AZT from rat brain

InhibitorConcentration in the Brain2-anPercentage Remaining in the Brain2-b
mM
Control3.3  × 10−5  AZT1553.8  ± 1.8
AZT3.3  × 10−3 356.4  ± 4.9
1.7  × 10−2 463.1  ± 8.5
3.3  × 10−2 468.7  ± 3.4**
  0.17 467.0  ± 5.0*
1.7 865.0  ± 3.8**
DDI1.7 464.3  ± 3.9*
Thymidine1.7 458.0  ± 2.9
3.3 455.4  ± 1.9
Probenecid3.3  × 10−3 455.1  ± 3.1
6.6  × 10−3 455.7  ± 4.4
3.3  × 10−2 465.9  ± 4.1**
  0.33 369.3  ± 6.0**
1.7 666.7  ± 2.6**
PAH3.3 867.6  ± 3.3**
PCG3.3 1066.9  ± 2.2**
DIDS3.3  × 10−2 764.2  ± 3.5**
  • 2-a The brain concentration was estimated from the injectate concentration divided by the dilution factor,i.e., 30.3, which was reported previously (Kakee et al., 1996).

  • 2-b The values were determined 20 min after intracerebral microinjection. Each value represents the mean ± S.E. * P < .05; ** P < .01.