Effect of SDZ HTF 919 on colonic phasic pressure activity (mean ± S.E.M.)
| Motility Index/hr | |||
|---|---|---|---|
| Fasting | After Drug | Postprandial | |
| Saline | 8.4 ± 1.0 | 8.8 ± 1.1 | 8.9 ± 0.9 |
| Vehicle | 8.2 ± 1.1 | 9.4 ± 0.7 | 9.6 ± 0.7 |
| SDZ HTF 919, 0.03 mg/kg | 8.0 ± 0.7 | 9.0 ± 0.5 | 9.2 ± 0.7 |
| SDZ HTF 919, 0.10 mg/kg | 8.6 ± 0.1 | 10.0 ± 0.3 | 9.7 ± 0.5 |
| SDZ HTF 919, 0.30 mg/kg | 8.0 ± 0.8 | 8.6 ± 0.6 | 8.5 ± 0.8 |