Interindividual variation in parathion oxidation in human hepatic microsomes
| Liver | Medication | 4-Nitrophenol | Paraoxon | Total |
|---|---|---|---|---|
| nmol/mg microsomal protein/min | ||||
| HL1 | Ranitidine | 1.02 | 0.70 | 1.72 |
| HL2 | Oxazepam, α-methyldopa | 1.02 | 0.87 | 1.89 |
| HL3 | Propranolol, furosemide, spironolactone, cimetidine | 1.03 | 1.31 | 2.34 |
| HL4 | None | 1.65 | 1.04 | 2.69 |
| HL5 | Unknown | 1.53 | 1.63 | 3.16 |
| HL6 | None | 1.78 | 1.75 | 3.53 |
| HL7 | Unknown | 1.53 | 2.02 | 3.55 |
| HL8 | None | 2.14 | 1.58 | 3.72 |
| HL9 | Furosemide, spironolactone | 1.82 | 2.29 | 4.11 |
| HL10 | Unknown | 1.98 | 2.14 | 4.12 |
| HL11 | Unknown | 2.56 | 1.67 | 4.23 |
| HL12 | Spironolactone | 2.26 | 3.03 | 5.29 |
| HL13 | Cefoxitin | 2.85 | 2.72 | 5.57 |
| HL14 | None | 2.26 | 3.37 | 5.63 |
| HL15 | Propranolol, spironolactone, ranitidine | 2.57 | 3.11 | 5.67 |
| HL16 | Unknown | 3.32 | 2.57 | 5.89 |
| HL17 | Colloidal bismuth subcitrate, sucralfate | 3.44 | 3.88 | 7.32 |
| HL18 | Norfloxacin, ranitidine, oxazepam | 4.07 | 3.29 | 7.36 |
| HL19 | None | 4.05 | 3.93 | 7.98 |
| HL20 | None | 4.46 | 4.43 | 8.89 |
| HL21 | Unknown | 4.77 | 4.15 | 8.92 |
| HL22 | Unknown | 8.16 | 6.06 | 14.22 |
| HL23 | None | 10.87 | 7.49 | 18.33 |
| Median | 2.26 | 3.03 | 5.29 | |
| Range | (1.02–10.87) | (0.70–7.49) | (1.72–18.33) | |