Table 4

Time course of cocaine-like discriminative stimulus effects for 0.2 mg/kg cocaine and 0.1 mg/kg PTT4-a

MonkeySalinePTT Vehicle0.2 mg/kg Coc
10-min5-hr1-hr5-hr10-min5-hr
987% Coc0.03  (0.0)0.02  (0.0)0.03  (0.0)0.02  (0.0)100  (0.0)0.06  (0.08)
Resp rate4-b 3.58  (0.67)3.78  (0.14)4.16  (0.05)3.96  (0.11)4.13  (0.13)3.88  (0.17)
9119% Coc0.00  (0.0)34.8  (37.2)0.00  (0.0)29.9  (40.4)100  (0.0)50.0  (2.9) 
Resp rate4-b 3.82  (0.50)3.99  (0.01)3.91  (0.00)3.81  (0.28)4.56  (0.12)4.30  (0.30)
9125% Coc0.09  (0.1)0.16  (0.2)0.00  (0.0)3.38  (4.9)100  (0.0)0.98  (1.4)
Resp rate4-b 3.24  (0.29)3.12  (0.15)2.74  (0.11)2.69  (0.50)3.62  (0.00)3.21  (0.13)
0.1 mg/kg PTT
10-min30-min1-hr5-hr8-hr24-hr
987% Coc100  (0.0)100  (0.0)100  (0.0)100  (0.0)35.4  (56.0)0.04  (0.1)
Resp rate4-b 3.95  (0.01)3.74  (0.06)4.06  (0.54)2.74  (0.16)4.01  (0.14)3.35  (0.03)
9119% Coc57.3  (12.7)77.3  (32.07)100  (0.0)94.3  (7.3)83.2  (15.03)31.0  (43.9)
Resp rate4.35  (0.37)4.20  (0.04)4.63  (0.23)3.02  (0.33)4.19  (0.47)3.55  (0.47)
9125% Coc100  (0.0)100  (0.0)99.3  (1.0)99.1  (1.1)99.7  (0.47)99.3  (1.0)
Resp rate3.88  (0.35)3.84  (0.23)3.92  (0.11)1.21  (0.12)2.77  (0.84)3.79  (0.06)
  • 4-a Each point is the mean of 2 determinations; numbers in parentheses are S.D.

  • 4-b Response rate (responses/sec).