Table 2

[3H]-mannitol and [14C]-nitrofurantoin transfer coefficients in the diffusion chamber

Direction of TransferTransfer Coefficient (cm/hr × 103)
No Nonlabelled Nitrofurantoin500 μM Nonlabelled Nitrofurantoin
Nitrofurantoin
 Apical to basal41.7  ± 0.5  (2)47.3  ± 1.7  (2)
 Basal to apical64.5  ± 4.0  (4)44.5  ± 0.7  (3)
Mannitol2-a
 Apical to basal9.1  ± 2.0  (6)
 Basal to apical6.7  ± 0.6  (18)
  • 2-a Values (mean ± S.E.M.) in the presence and in the absence of nitrofurantoin were not different and have been lumped.

  • Numbers in parenthese are the number of filters studied.