Table 1

Coefficients for [14C]-nitrofurantoin and [3H]-mannitol transfer across transwell filters1-a

ParameterBasal to ApicalApical to Basal
[14C]-Nitrofurantoin[3H]-Mannitol[14C]-Nitrofurantoin[3H]-Mannitol
Concentration ratio at 8 hr: donor to receiver1.83  ± 0.080.04  ± 0.020.100  ± 0.0010.013  ± 0.001
Transfer coefficient1-b(cm/hr)(62.9  ± 2.7)  × 10−3 (1.6  ± 0.2)  × 10−3 (9.5  ± 0.4)  × 10−3 (1.3  ± 1.0)  × 10−3

  • ↵1-a Calculated from data in figure 1.

  • ↵1-b Calculated from the flux rates for the first 3 hr as described in “Materials and Methods.”