Table 1

ED50 values (mg/kg) for cocaine and PTT as a function of session time1-a

Pretreatment1-hr2-hr3-hr4-hr
0.03 mg/kg/inj cocaine
PTT0.300.140.130.07
(0.06–1.6)(0.06–0.30)(0.07–0.24)(0.03–0.15)
Cocaine0.701.29Not effective1-b Not effective1-b
(0.40–1.2)(0.62–2.7)
0.1 mg/kg/inj cocaine
PTTNot effective1-c 0.110.060.11
(0.02–0.65)(0.01–0.47)(0.03–0.42)
Cocaine1.14Not effective1-b Not effective1-b Not effective1-b
(0.39–3.4)
  • 1-a Values were calculated from response rate data; numbers in parentheses are ± 95% confidence limits.

  • 1-b Response rates were ≥50% of base-line rates at the highest dose tested (3.0 mg/kg cocaine).

  • 1-c Response rates were ≥50% of base-line rates at the highest dose tested (0.3 mg/kg PTT).