Table 8

The effects of amisulpride, haloperidol, sulpiride and clozapine on rat striatal ACh and choline levels

DrugDose (mg/kg i.p.)Nanomoles per Gram of Wet Tissue Weight
AChCholine
Control16  ± 1184  ± 6
Amisulpride0.116  ± 2175  ± 7
0.516  ± 1176  ± 10
2.514  ± 1173  ± 7
1016  ± 1190  ± 12
3014  ± 1* 194  ± 9
1009  ± 1*** 182  ± 11
Haloperidol0.211  ± 1** 175  ± 7
Sulpiride10010  ± 0*** 181  ± 10
Clozapine1013  ± 1189  ± 12

Animals were sacrificed 120 min after injection of drugs, and tissue levels of ACh and choline were determined by HPLC with electrochemical detection. Data are the mean and S.E.M. of six animals for each experimental group.

  • * P < .05, ** P < .01, *** P < .001 compared with the control group (n = 6/group).