Table 5

Effects of amisulpride on dopamine synthesis in the rat brain

DrugDose (mg/kg i.p.)Dopa Level (ng/g wet tissue weight)
StriatumLimbic System
Control932  ± 20537  ± 31
(100  ± 2)(100  ± 6)
Amisulpride0.21035  ± 73604  ± 30
(111  ± 8)(112  ± 6)
21135  ± 48678  ± 60
(122  ± 5)(126  ± 11)
202027  ± 100** 1047  ± 120*
(217  ± 11)(195  ± 22)
1003384  ± 629** 1406  ± 58**
(363  ± 67)(262  ± 11)
Control1451  ± 86710  ± 33
(100  ± 6)(100  ± 5)
Haloperidol0.031440  ± 101690  ± 43
(99  ± 7)(97  ± 6)
0.13377  ± 362* 1070  ± 135*
(233  ± 25)(151  ± 19)
0.35306  ± 252* 1395  ± 81*
(366  ± 17)(196  ± 11)

Rats received NSD-1015 (100 mg/kg) 90 min after the administration of amisulpride or its vehicle control and were sacrificed 30 min thereafter. Data are expressed as the mean and S.E.M. (n = 3–7/group). Dopa levels calculated as a percentage of the corresponding control groups are shown in parentheses.

  • * P < .05, ** P < .01 against respective controls.