Table 4

Effects of amisulpride on dopamine and DOPAC levels in the rat brain

DrugDose (mg/kg i.p.)Nanograms per Gram of Wet Tissue Weight
StriatumLimbic System
DopamineDOPACDopamineDOPAC
Control8560  ± 427821  ± 503635  ± 86403  ± 13
(100.0  ± 5.0)(100.0  ± 6.1)(100.0  ± 2.4)(100.0  ± 3.2)
Amisulpride0.18244  ± 281815  ± 403574  ± 164403  ± 18
(96.3  ± 3.3)(99.3  ± 4.9)(98.3  ± 4.5)(100.0  ± 4.5)
0.58133  ± 292822  ± 443759  ± 151429  ± 15
(95.0  ± 3.4)(100.1  ± 5.4)(103.4  ± 4.2)(106.5  ± 3.7)
2.57952  ± 323910  ± 523853  ± 221507  ± 33**
(92.9  ± 3.8)(110.8  ± 6.3)(106.0  ± 6.1)(125.8  ± 8.2)
108194  ± 3811189  ± 87** 3781  ± 142678  ± 47***
(95.7  ± 4.5)(144.8  ± 10.6)(104.0  ± 3.9)(168.2  ± 11.7)
307811  ± 3701549  ± 114*** 3234  ± 207828  ± 69**
(91.3  ± 4.3)(188.7  ± 13.9)(89.0  ± 5.7)(205.5  ± 17.1)
1007169  ± 350* 2339  ± 136*** 3007  ± 146** 1287  ± 53***
(83.8  ± 4.1)(284.9  ± 16.6)(82.7  ± 4.0)(319.4  ± 13.2)
Haloperidol0.27903  ± 4052824  ± 179*** 3528  ± 981062  ± 41***
(92.3  ± 4.7)(344.0  ± 21.8)(97.1  ± 2.7)(263.5  ± 13.2)
Sulpiride1007828  ± 3722378  ± 172*** 3281  ± 117* 1096  ± 72***
(91.4  ± 4.3)(289.6  ± 21.0)(90.3  ± 3.2)(272.0  ± 17.9)
Clozapine108749  ± 2831302  ± 38*** 3917  ± 170700  ± 25***
(102.2  ± 3.3)(158.6  ± 4.6)(107.8  ± 4.7)(173.7  ± 6.2)

Animals were sacrificed 120 min after injection of drugs, and tissue levels of dopamine and DOPAC were determined by HPLC with electrochemical detection. Data are the mean and S.E.M. of 12 animals for each experimental group and are presented as absolute levels and (in parentheses) as a percentage of the corresponding control value.

  • * P < .05, ** P < .01, *** P < .001 compared with the corresponding control group.