Parameter1-a | Group | Control | Ischemia | Reperfusion | |||
---|---|---|---|---|---|---|---|
15 min | 60 min | 120 min | 180 min | ||||
HR (beats/ | Vehicle | 92 ± 17 | 124 ± 12 | 133 ± 7 | 126 ± 7 | 136 ± 8 | 142 ± 10 |
min) | CGS-21680 | 94 ± 12 | 118 ± 12 | 139 ± 11 | 139 ± 12 | 116 ± 7 | 115 ± 7* |
LVSP (mm | Vehicle | 111 ± 6 | 104 ± 4† | 105 ± 6 | 107 ± 6 | 103 ± 7 | 98 ± 4 |
Hg) | CGS-21680 | 115 ± 6 | 114 ± 8 | 103 ± 4 | 99 ± 3 | 96 ± 3 | 97 ± 2 |
LVEDP (mm | Vehicle | 8.5 ± 1.4 | 13.7 ± 3.6 | 12.1 ± 1.3 | 9.9 ± 1.3 | 9.3 ± 1.3 | 9.1 ± 1.3 |
Hg) | CGS-21680 | 11.9 ± 1.5 | 14.1 ± 1.5 | 12.9 ± 2.3 | 9.8 ± 1.9 | 10.4 ± 1.8 | 10.8 ± 1.7 |
MAP (mm Hg) | Vehicle | 95 ± 5 | 95 ± 4 | 95 ± 4 | 96 ± 6 | 92 ± 7 | 88 ± 4 |
CGS-21680 | 99 ± 7 | 99 ± 9 | 86 ± 7 | 79 ± 5* | 78 ± 5 | 80 ± 5 | |
PRP · 1000 | Vehicle | 9.8 ± 1.6 | 12.8 ± 1.3 | 13.9 ± 0.7 | 13.4 ± 0.9 | 14.0 ± 1.2 | 14.1 ± 1.5 |
(mm Hg sec) | CGS-21680 | 11.0 ± 1.7 | 13.7 ± 2.2 | 14.4 ± 1.5 | 13.7 ± 1.2 | 11.1 ± 0.8 | 11.2 ± 0.8 |
dP/dt max (mm | Vehicle | 1716 ± 89 | 1417 ± 92 | 1342 ± 124 | 1445 ± 123 | 1423 ± 112 | 1337 ± 95 |
Hg/sec) | CGS-21680 | 1700 ± 134 | 1506 ± 100 | 1441 ± 75 | 1555 ± 88 | 1310 ± 76 | 1292 ± 99 |
dP/dt min (mm | Vehicle | −1788 ± 101 | −1452 ± 104 | −1479 ± 135 | −1573 ± 115 | −1519 ± 118 | −1417 ± 117 |
Hg/sec) | CGS-21680 | −1789 ± 94 | −1625 ± 138 | −1437 ± 21 | −1452 ± 38 | −1372 ± 48 | −1349 ± 103 |
CBF (ml/min) | Vehicle | 20.6 ± 1.8 | 35.6 ± 2.7† | 32.3 ± 2.4 | 22.4 ± 2.8† | 19.8 ± 1.6 | |
CGS-21680 | 25.6 ± 1.5 | 56.3 ± 3.5† * | 51.6 ± 2.7* | 23.7 ± 2.0† | 21.9 ± 2.3 |
↵1-a HR, heart rate; LVSP, LV peak systolic pressure; LVEDP, LV end-diastolic pressure; CBF, mean coronary (LAD) blood flow. Values are expressed as mean ± S.E.M.
* P < .05 vs. vehicle-treated group.
† P < .05 vs. prior time point.