K i values of adenosine agonists and antagonists for rabbit A1 and A3 receptors
| Ki 1-a | ||
|---|---|---|
| Rabbit A1 | Rabbit A3 | |
| nm | ||
| Adenosine agonists | ||
| IB-MECA | 30 ± 3 | 2 ± 1 |
| I-ABA | 4 ± 2 | 5 ± 1 |
| NECA1-b | 2 ± 0.1 | 27 ± 9 |
| APNEA | 6 ± 1 | 47 ± 11 |
| (R)-PIA | 1 ± 0.2 | 49 ± 11 |
| CPA | 1 ± 0.1 | 49 ± 8 |
| ABA | 40 ± 3 | 169 ± 23 |
| Adenosine antagonists | ||
| XAC | 5 ± 1 | 329 ± 80 |
| BWA1433 | 3 ± 1 | 746 ± 105 |
| DPCPX | 1 ± 0.1 | 1,120 ± 145 |
| 8-SPT | 430 ± 279 | 37,797 ± 4,409 |
↵1-a K i values for inhibition of125I-ABA binding were determined as described in “Methods.” Data are presented as mean ± S.E. of three to six experiments.
↵1-b NECA, N-ethylcarboxamidoadenosine; APNEA;N 6-2-(4-aminophenyl) ethyladenosine; XAC, xanthine amine congener; 8-SPT, 8-(p-sulfophenyl) theophylline.