Plasma, brain, and brain-to-plasma concentration ratios of [3H]digoxin radioactivity in wild-type and P-gp double-knockout mice after intravenous administration of 0.5 mg/kg [3H]digoxin (arithmetic means) (n = 3 animals per time point)
| Time | Plasma Concentration Ratio of Wild-Type and P-gp Double-Knockout Mice | Brain Concentration Ratio of Wild-Type and P-gp Double-Knockout Mice | Brain-to-Plasma Concentration Ratio of Wild-Type Mice | Brain-to-Plasma Concentration Ratio of P-gp Double-Knockout Mice | Quotient of Brain-to-Plasma Concentration Ratio of Wild-Type and P-gp Double-Knockout Mice (Arithmetic Mean) |
|---|---|---|---|---|---|
| min | |||||
| 5 | 1.20 | 4.32 | 0.0276 | 0.096 | 3.60 |
| 15 | 1.64 | 9.70 | 0.034 | 0.201 | 5.90 |
| 30 | 1.88 | 15.0 | 0.044 | 0.350 | 7.96 |
| 60 | 1.92 | 25.8 | 0.053 | 0.710 | 13.5 |
| 120 | 2.53 | 33.5 | 0.092 | 1.21 | 13.2 |
| 240 | 3.45 | 44.1 | 0.195 | 2.51 | 12.9 |
| 420 | 7.74 | 65.1 | 0.498 | 4.15 | 8.32 |