Parameter | Description | Estimate | CV (%) | i.i.v (%) |
---|---|---|---|---|
Kmax | Maximal tumor kill rate | 10 | 0 | — |
KC50 (ng/mL) | Concentration leading to 50% of Kmax | 370 | 12 | — |
Lambda (1/h) | Decrease of drug effect over time | 0.01 | 8 | — |
Kg (1/h) | Tumor growth rate | 0.03 | 6 | 33 |
Kkill (1/h) | Tumor kill rate | 0.07 | 6 | — |
TV0 (mm3) | Initial tumor volume | 171 | 5 | 26 |