Plasma pharmacokinetic in the 8-week Sugen 5416/hypoxia study
(A) Concentration of treprostinil (TRE) in the plasma after inhalation of TPIP at 59 and 117 μg/kg (once daily), inhaled TRE at 65 mg/kg (4× daily), and intravenous (i.v.) TRE at 810 ng/kg per min.
| Plasma TRE (ng/ml) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 59 μg/kg TPIP (once daily) | 117 μg/kg TPIP (once daily) | 65 mg/kg inhaled TRE (4× daily) | 810 ng/kg per min i.v. TRE | |||||||||
| Day | 22 | 38 | 56 | 22 | 38 | 56 | 22 | 38 | 56 | 22 | 35–38 | 56 |
| Average | 0.00 | 0.19 | 0.12 | 0.00 | 0.14 | 0.08 | 0.09 | 0.22 | 0.13 | 39.35 | 12.36 | 7.57 |
| S.E.M. | 0.05 | 0.03 | 0.03 | 0.02 | 0.03 | 0.04 | 0.03 | 6.44 | 1.36 | 0.93 | ||
| n | 11 | 11 | 11 | 11 | 10 | 10 | 11 | 11 | 10 | 13 | 13 | 13 |