TABLE 2

Population pharmacokinetic parameter estimates of JNJ-73763989

All volumes and clearances were allometrically scaled and centered around the mean mouse body weight of 26.7 g. Liver volumes were scaled based on the calculated liver density of 1.088 mL g⁻¹.

Parameter	Unit	Parameter estimate (RSE%)
F	%	100 (fixed)
k_a	h⁻¹	0.2341 (2.2)
CL_p_, _S	mL ⋅ h⁻¹ ⋅ 26.7 g⁻¹	11.00 (5.2)
CL_p_, _X	mL ⋅ h⁻¹ ⋅ 26.7 g⁻¹	20.12 (2.6)
V_C	mL ⋅ 26.7 g⁻¹	1.992 (12.7)
Q	mL ⋅ h⁻¹ ⋅ 26.7 g⁻¹	1.726 (24.8)
V_P	mL ⋅ 26.7 g⁻¹	2.252 (17.4)
CL_l_,_S	mL ⋅ h⁻¹ ⋅ 26.7 g⁻¹	0.00196 (5.3)
CL_l_, _X	mL ⋅ h⁻¹ ⋅ 26.7 g⁻¹	0.00164 (1.6)
V_L	mL ⋅ 26.7 g⁻¹	0.8711 (9.6)
K_SS_,_S	nM	143.2 (16.0)
K_SS_, _X	nM	73.7 (14.8)
k_int	h⁻¹	1.925 (14.0)
R_tot	nM	647 (fixed, Bon et al.)
	%	33.00 (14.7)
	%	29.11 (7.9)
	%	38.30 (8.5)
	%	10.32 (15.9)
	%	9.67 (15.4)

ω, inter-individual variability on the CV scale; σ, residual unexplained variability on the CV scale.