(B) Concentration of selexipag and its metabolite ACT-333679 in the plasma after oral administration of selexipag at 30 mg/kg.

Blood samples for all groups were collected at day 22, day 38, and day 56. Details of the blood sample collection are described in the Materials and Methods section.

Plasma Selexipag and Metabolite (ng/ml)
30 mg/kg selexipag (twice daily)30 mg/kg selexipag metabolite (ACT-333679) (twice daily)
Day223856223856
Average11.370.565.402512.94817.58330.89
S.E.M.3.030.313.00268.61147.2580.96
n10991099