TABLE 2
Hemodynamics and airway remodeling in the 8-week Sugen 5416/hypoxia (Su/Hx) study
Values represent the mean ± S.E.M % inhibition due to treatments of the mPAP, CO, Fulton index, percentage of wall thickness, percentage of muscularization, percentage of nonobliterated pulmonary arteries, or the combined total of these values in Su/Hx rats. n represents the number of determinations. The last column shows the average of all six individual parameters.
| Parameter (% Inhibition) † | ||||||||
|---|---|---|---|---|---|---|---|---|
| Drug | Dose | mPAP | CO | Fulton Index | Wall Thickness | Muscularization | Obliteration | Combined Average |
| TPIP (inhaled, once daily) | 59 μg/kg | 53 ± 6 | 29 ± 14 | 41 ± 18 | 50 ± 8 | 25 ± 3 | 17 ± 13 | 36 ± 4 |
| n | 11 | 11 | 6 | 11 | 11 | 11 | 61 | |
| TPIP (inhaled, once daily) | 117 μg/kg | 80 ± 8 | 66 ± 15 | 69 ± 7 | 55 ± 13 | 45 ± 7 | 69 ± 7 | 63 ± 4 |
| n | 10 | 10 | 5 | 10 | 10 | 10 | 55 | |
| TRE (inhaled, 4× daily) | 65 μg/kg | 34 ± 17 | 58 ± 41 | 7 ± 33 | 19 ± 18 | 26 ± 7 | 63 ± 13 | 37 ± 9 |
| n | 10 | 10 | 5 | 10 | 10 | 10 | 55 | |
| TRE (i.v.) | 810 ng/kg per min | 43 ± 10 | 48 ± 22 | 16 ± 13 | 43 ± 7 | 15 ± 4 | 31 ± 9 | 34 ± 5 |
| n | 13 | 13 | 6 | 13 | 13 | 13 | 71 | |
| Selexipag (oral, twice daily) | 30 mg/kg | 59 ± 15 | 11 ± 26 | 53 ± 15 | 58 ± 16 | 35 ± 10 | 29 ± 7 | 40 ± 7 |
| n | 10 | 10 | 5 | 9 | 9 | 9 | 520 | |
