TABLE 4

Lung pharmacokinetic in the 8-week Sugen 5416/hypoxia study

(A) Concentration of treprostinil (TRE) in the lung after inhalation of TPIP at 59 and 117 μg/kg (once daily), inhaled TRE at 65 mg/kg (4× daily), and intravenous (i.v.) TRE at 810 ng/kg per min.

Lung TRE (ng/g)
59 mg/kg TPIP (once daily)117 mg/kg TPIP (once daily)65 mg/kg inhaled TRE (4× daily)810 ng/kg per min i.v. TRE
Average3.326.350.061.75
S.E.M.0.671.560.040.51
n11101011